An Indian Mission School, along the banks of the Grand River, and run by Leonard Slater, eventually became the First Congregational Society of Grandville in 1838. Its Articles of Faith and Covenant were adopted on April 25, 1839 and a building erected in 1855. In 1889 the church’s name became The First Congregational Church of Grandville and Articles of Incorporation and Association were adopted.

Due to a lack of leadership the church closed for a few years from 1903 until 1907. During this time the Congregational Church of Jenison was organized and a frame building erected in 1905. By 1925 the Jenison Church was struggling due to the loss of its aging congregation. A young graduate of Chicago Theological Seminary, Harold T. Janes, was called to serve as pastor and was successful in reviving the church.

In 1907 Rev. Mortier C. Bullock was sent by the Congregational Union of Grand Rapids to reopen and reorganize the First Congregational Church of Grandville. The church grew and membership was 130 by 1912. A new church building was constructed in 1916. From 1907 through 1923 the Grandville and Jenison Congregational Churches shared a pastor but not a building.

In the 1930s a doctrinal and governmental controversy erupted in the First Congregational Church of Grandville resulting in by-laws amended to ensure only a minister sympathetic to the doctrines and practices of the Congregational Church would serve the church.

In 1934 discussions of a merger of the Congregational Church of Jenison and the First Congregational Church of Grandville began. The churches began meeting in the Grandville building in 1935. On April 22, 1935 the churches formally merged and became the Grandville-Jenison Congregational Church. The Rev. C.H. Stowe was called to serve the new church.

A fire destroyed the church on New Year’s Day in 1944 and the bell was all that survived. A new, all purpose building was built on Henry Street in 1948. In 1961 the church voted to become a part of the United Church of Christ. Shortly thereafter a new church sanctuary was built and completed in 1964, where the church bell was placed in the tower.

In 1994 the membership voted to drop membership in the United Church of Christ and join the Conservative Congregational Christian Conference. In 2010 the church dropped their affiliation with the CCCC and voted to have no affiliation with a national organization.